HIV-1/HTLV-II Coinfection: HIV-1/HTLV-II coinfection associated with greater immunodeficiency

AIDSWEEKLY Plus; Monday, May 15, 2006
Staff Medical Writers

According to a recently published report from Mexico, "The HTLV-II infection has been reported in patients with HIV infection as often in asymptomatic as those with acquired immunodeficiency syndrome (AIDS).

"The aim of this study was to determine the prevalence of HTLV-II infection in a group of patients infected by HIV in our region, as well as determining the risk factors associated with HTLV-II transmission in this group of patients and its impact on the clinical course of HIV infection."

"A cross-sectional study was carried out to determine the prevalence of coinfection of HIV-I and HTLV-II among 192 patients from Yucatan, Mexico. Serum specimens were tested for HTLV antibodies by an enzyme-linked immunosorbent assay (ELISA) test. Positive results were confirmed and typed by Western blot," researchers said.

C.J. Castro-Sansores and colleagues at University of Autonoma Yucatan in Merida reported, "Twenty four (12.5%) patients were confirmed with antibodies for HTLV-II, but none had antibodies for HTLV-I.

"Specific risk factors for HTLV-II transmission were not identified. Candidiasis (42 vs. 12%, p=0.0004) and more than two defining entities of AIDS (37 vs. 18%, p=0.02) was observed with greater prevalence in the group coinfected."

"In our study," researchers concluded, "higher frequency of candidiasis and a larger number of AIDS-defining pathologies were observed in the coinfected patients, suggesting that coinfection is associated with greater immunodeficiency."

Castro-Sansores and colleagues published their study in Archives of Medical Research (Coinfection by the human T-Cell lymphotropic virus type II in patients infected by the human immunodeficiency virus in Yucatan, Mexico. Arch Med Res. 2006 Apr;37(3):365-9).

For additional information, contact C.J. Castro-Sansores, University of Autonoma Yucatan, Hematology Laboratory, Reg Research Center Dr. Hideyo Noguchi, Av Itzaes 490 & 59, Center, Merida 97000, Yucutan, Mexico.

The publisher's contact information for the journal Archives of Medical Research is: Elsevier Science Inc., 360 Park Avenue South, New York, NY 10010-1710, USA.

Keywords: Merida, Mexico, HIV-1/HTLV-II Coinfection, Immunodeficiency, AIDS-Defining Illness.

This article was prepared by AIDS Weekly editors from staff and other reports.

Reference

Castro-Sansores CJ, Santos-Rivero A, Gonzalez-Martinez P, et al., "Co-infection by the human T-cell lymphotropic virus type II in patients infected by the human immunodeficiency virus in Yucatan, Mexico", Arch Med Res. 2006 Apr;37(3):365-9.

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