AIDSWEEKLY Plus; Monday, October 3, 2005
Staff Medical Writers

"The acute-phase protein C-reactive protein (CRP) is a sensitive marker of inflammation and tissue damage. We measured CRP in 109 HIV-1 antibody-positive patients admitted to hospital for investigation," researchers in United Kingdom report.

"In 67 patients with intercurrent infection (of whom 27 were afebrile at presentation) CRP levels were 2.2-483.5 mg/dL (normal value in the general population <3 mg/dL) and in 42 patients with alternative noninfection diagnoses CRP levels were 0.5-108.6 (median=5.9) mg/dL.

"Whereas in those with infections," M. Noursadeghi and colleagues at the University College London wrote, "elevated CRP levels fell in response to specific therapy, values remained abnormal in those with noninfection diagnoses."

The authors concluded, "CRP appears useful for diagnosis and monitoring of intercurrent infection in HIV-1 antibody-positive patients.

"In HIV-1 antibody-positive patients without intercurrent infection, CRP values higher than in the general population possibly reflect a sustained acute-phase response as a consequence of HIV infection per se."

Noursadeghi and colleagues published their study in International Journal of STD & AIDS (Clinical value of C-reactive protein measurements in HIV-positive patients. Int J STD AIDS. 2005 Jun;16(6):438-41.

For additional information, contact M. Noursadeghi, University of College London Hospitals Trust, Patrick Manson Unit, London, United Kingdom.

Publisher contact information for the International Journal of STD & AIDS is: Royal Society Medicine Press Ltd., 1 Wimpole Street, London W1G 0AE, England.

Keywords: London, United Kingdom, HIV/AIDS, C-Reactive Protein, Intercurrent HIV-1 Infection, Prognostic Indicator, HAART.

This article was prepared by AIDS Weekly editors from staff and other reports.

Reference

Noursadeghi M, Miller RF. Clinical value of C-reactive protein measurements in HIV-positive patients, Int J STD AIDS. 2005 Jun;16(6):438-41.

PubMED Related articles Search

051003
AW051001

Copyright © 2005 - Charles Henderson, Publisher. All rights Reserved. Permission to reproduce granted to AEGIS by Charles W. Henderson. Authorization to reproduce for personal use granted granted by C. W. Henderson, Publisher, provided that the fee of US$4.50 per copy, per page is paid directly to the Copyright Clearance Center, 27 Congress Street, Salem, Massachusetts 01970, USA. Published by Charles Henderson, Publisher. Editorial & Publishing Office: P.O. Box 5528, Atlanta, GA 30307-0528 / Telephone: (800) 633-4931; Subscription Office: P.O. Box 830409, Birmingham, AL 35283-0409 / FAX: (205) 995-1588 http://www.newsrx.net

AEGiS is made possible through unrestricted grants from Boehringer Ingelheim, Elton John AIDS Foundation, Bridgestone/Firestone Charitable Trust, the National Library of Medicine, and donations from users like you. Always watch for outdated information. This article first appeared in 2005. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright © 1980,2005. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content.