AIDSWEEKLY Plus; Monday, July 18, 2005
Staff Medical Writers

"Strong T cell and antibody responses to human immunodeficiency virus (HIV), low virus production, and some genetic traits have been individually associated with nonprogression of HIV infection, but the best correlate with protection against disease progression remains unknown.

"We prospectively followed 66 untreated long-term nonprogressors and analyzed relationships between HIV-1-specific CD4 T helper (Th) 1 and CD8 T cell responses and HIV-1-specific antibodies, HIV-1 RNA and proviral DNA loads, host genes, and CD4 Th1 cell counts at entry into the study and 4 years later," scientists in France report.

"HIV-1 p24-specific CD4 Th1 cell proliferation, interferon (IFN)-gamma production, and IFN-gamma-producing cell frequencies at entry significantly and negatively correlated with HIV-1 RNA and proviral DNA loads and were independent of CD4 Th1 cell counts and host genes.

"HIV-1 Gag-specific IFN-gamma-producing CD8 T cell frequencies correlated with HIV-1 proviral DNA loads but not with RNA loads. Only high frequencies of HIV-1 p24-specific CD4 Th1 cells combined with HIV-1 gp41-specific IgG2 antibodies significantly predicted persistence of high CD4 Th1 cell counts," wrote V. Martinez and colleagues at the University of Paris.

Investigators concluded, "HIV-1-specific CD4 Th1 responses combined with IgG2 antibodies and IFN-gamma-producing CD4 Th1 cells are better predictors of long-term nonprogression than are virus parameters, host genes, or HIV-1 -specific CD4 Th1 or CD8 T cell proliferation."

Martinez and colleagues published their study in the Journal of Infectious Diseases (Combination of HIV-1-specific CD4 Th1 cell responses and IgG2 antibodies is the best predictor for persistence of long-term nonprogression. J Infect Dis. 2005 Jun 15;191(12):2053-63.

For additional information, contact B. Autran, University of Paris 06, Laboratory Immunology Cellulaire & Tissulaire, INSERM, U543, Hop La Pitie Salpetriere, 83 Bld Hop, F-75013 Paris, France.

The publisher's contact information for the Journal of Infectious Diseases is: University Chicago Press, 1427 E 60th St., Chicago, IL 60637-2954, USA.

Keywords: Paris, France, HIV/AIDS, Long-Term Nonprogression, Prognostic Indicator, CD4 Cells, Viral Load, IgG2 Antibody Production.

This article was prepared by AIDS Weekly editors from staff and other reports.

Reference

Martinez V, Costagliola D, Bonduelle O, et al., Combination of HIV-1-specific CD4 Th1 cell responses and IgG2 antibodies is the best predictor for persistence of long-term nonprogression, J Infect Dis. 2005 Jun 15;191(12):2053-63.

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