Important note: Information in this article was accurate in November 2003. The state of the art may have changed since the publication date. |
AIDSWEEKLY Plus; Monday, November 3, 2003
Staff Medical Writers
FDG-PET is already known to detect "active lymphoid tissues during HIV-1 infection in man," scientists in the United States noted.
A.M. Scharko and colleagues at the University of Maryland "used FDG-PET to study anatomical correlates of HIV-1 infection" in humans.
"Whole-body FDG-PET images from 15 patients with HIV-1 showed distinct lymphoid tissue activation in the head and neck during acute disease, a generalized pattern of peripheral lymph-node activation at mid-stages, and involvement of abdominal lymph nodes during late disease," they reported.
"Unexpectedly, HIV-1 progression was evident by distinct anatomical correlates," study data showed, "suggesting that lymphoid tissues are engaged in a predictable sequence."
"Understanding the anatomy of HIV-1 infection could encourage use of surgical or radiological interventions to supplement chemotherapy," the researchers concluded.
Scharko and coauthors published their study in Lancet (Whole-body positron emission tomography in patients with HIV-1 infection. Lancet. 2003 Sep 20;362(9388):959-61.
For more information, contact C.D. Pauza, University of Maryland, Biotechnology Institute, Institute of Human Virology, 725 W. Lombard St., Baltimore, MD 21201 USA.
Publisher contact information for the journal Lancet is: Lancet Ltd., 84 Theobalds Rd., London WC1X 8RR, UK.
The information in this article comes under the major subject areas of AIDS & HIV, Medical Devices and Virology.
This article was prepared by AIDS Weekly editors from staff and other reports.Reference
Scharko AM, Perlman SB, Pyzalski RW, et al. "Whole-body positron emission tomography in patients with HIV-1 infection", Lancet. 2003 Sep 20;362(9388):959-61
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