Important note: Information in this article was accurate in June 2000. The state of the art may have changed since the publication date.AIDSWEEKLY Plus; Monday, June 12, 2000
Prepared by AIDS Weekly editors from staff and other reports
NewsRx -- Medical investigators at Indiana University's School of Medicine report that patients taking the drug indinavir, an antiretroviral agent used in treating patients with the human immunodeficiency virus (HIV), has caused asymptomatic crystalluria and acute interstitial nephritis in at least two of their patients.
In describing some of the symptomatology associated with these kidney disorders, M. Jaradat and colleagues said, "Patients taking indinavir may present with asymptomatic crystalluria, nephroliathiasis with frank renal colic and obstruction, flank pain in the absence of nephrolithiasis, and dysuria or urgency."
These two patients were asymptomatic for crystalluria, but an analysis of their urine revealed crystals in white blood cell clumps ("Acute tubulointerstitial nephritis attributable to indinavir therapy," Am J Kidney Dis 2000 Apr;35(4):E16.
Jaradat's group suggested that an increased inflammatory response was responsible for this condition, stating, "Both cases show that the inflammatory response was significant enough to lead to tubular injury and acute renal impairment."
Based on these findings in the HIV infected patients, Jaradat and colleagues suggested that patients who take indinavir should be monitored for kidney function.
The corresponding author for this study is M. Jaradat, Indiana University, School of Medicine, Wishard Memorial Hospital, Division of Nephrology, 1001 W 10th Street, OPW 526, Indianapolis, Indiana 46202, USA.
Key points reported in this study are:
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