AIDSWEEKLY Plus; Monday, April 6, 1998
Daniel J. DeNoon, Senior Editor
The novel plasmids have successfully delivered DNA encoding HIV or herpes simplex antigens in the mouse model, reported Douglas Jolly of Chiron Technologies, San Diego, California.
"For considerably less DNA you get more bang for your DNA buck," Jolly said in a presentation to the workshop "Virus Vectors for AIDS Vaccines" sponsored by the Division of AIDS, National Institute of Allergy and Infectious Diseases, held March 4, 1998, in Palm Springs, California, in association with the 1998 Palm Springs Symposium on HIV/AIDS.
He noted that the vectors, based on Sindbis virus, yield 30- to 100-fold more potent responses than more conventional DNA vectors. In mouse experiments, a plasmid encoding the herpes simplex glycoprotein B elicited significant immune responses at doses as low as 10 nanograms.
A report on these experiments recently appeared in the Journal of Virology ("DNA Immunization against Herpes Simplex Virus: Enhanced Efficacy Using a Sindbis Virus-Based Vector," Hariharan, M.J. et al., J Virol, 1998;72(2):950--8).
Jolly said his laboratory currently is working to determine the dosage needed to elicit immune responses in monkeys.
"If we could do this in primates, it would really be interesting," he speculated.
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